Shalbactam TZ should be administered by either intravenous or intramuscular route 

Adults:

• The usual adult daily dose of Shalbactam TZ is 1.125 to 2.250 grams given once a day (or in equally divided doses twice a day) depending on the type and severity of infection. The total daily dose should not exceed 4.5 grams.  

• For preoperative use (surgical prophylaxis), a single dose of 1.125 gm administered intravenously ½ to 2 hours before surgery is recommended 

Pediatric patients:  

• For the treatment of skin and skin structure infections: Recommended total daily dose of ceftriaxone is 50mg to 75mg/kg given once a day (or in equally divided doses twice a day). The total daily doses of Shalbactam TZ should not exceed 2.250 grams.  
• For the treatment of acute bacterial otitis media, a single intramuscular Ceftriaxone dose of 50mg/kg (total combination dose not to exceed 1.125 gram) is recommended 
• For the treatment of serious miscellaneous infections other than meningitis, the recommended total daily dose is 50mg to 75mg/kg, given in divided doses every 12 hours. The total daily dose of the combination should not exceed 2.250 grams.  

• In the treatment of meningitis, it is recommended that the initial therapeutic dose of ceftriaxone be 100mg/kg (total dose not to exceed 4.5 g). The daily dose may be administered once a day (or in equally divided doses every 12 hours). The usual duration of therapy is 7 to 14 days .