Adults

Gastro-Esophageal Reflux Disease (GERD)

• Treatment of erosive reflux esophagitis: 40mg once daily for 4 weeks.
• Long-term management of patients with healed esophagitis to prevent relapse: 20mg once daily.
• Symptomatic treatment of GERD: 20mg once daily in patients without esophagitis. If symptom control has not been achieved after 4 weeks, the patient should be further investigated. Once symptoms have resolved, subsequent symptom control can be achieved using 20mg once daily. In adults, an on-demand regimen taking 20mg once daily, when needed, can be used.

In combination with appropriate antibacterial therapeutic regimens for the eradication of Helicobacter pylori, Healing of Helicobacter pylori associated duodenal ulcer and prevention of relapse of peptic ulcers in patients with Helicobacter pylori associated ulcers: 20mg esomeprazole with 1g amoxicillin and 500mg clarithromycin, all twice daily for 7 days.

Patients requiring continued NSAID therapy

• Healing of gastric ulcers associated with NSAID therapy: 20mg once daily for 4-8 weeks.
• Prevention of gastric and duodenal ulcers associated with NSAID therapy in patients at risk: 20mg once daily.

Prolonged treatment after I.V. induced prevention of rebleeding of peptic ulcers: 40mg once daily for 4 weeks

Treatment of Zollinger Ellison Syndrome: 40mg twice daily. With doses above 80 mg daily, the dose should be divided and given twice daily.