Corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes. Gentamicin is an aminoglycoside that binds to 30s and 50s ribosomal subunits of susceptible bacteria disrupting protein synthesis, thus rendering the bacterial cell membrane defective. Tolnaftate is an antifungal which inhibits growth of dermatophytes. Iodochlorhydroxyquinoline has antibacterial and antifungal activity.

Betamethasone: Dermal atrophy, local irritation, folliculitis, hypertrichosis. Abrupt withdrawal leading to acute adrenal insufficiency manifesting as malaise, weakness, mental changes, muscle and joint pains, dystonia, hypoglycaemia, hypotension, dehydration and death. Gentamicin: Dizziness or vertigo; acute renal failure, interstitial nephritis, acute tubular necrosis; electrolyte imbalances; transient elevation of serum bilirubin and aminotransferases; purpura; nausea, vomiting; convulsions, mental depression, hallucinations. Tolnaftate: Irritation, pruritus, contact dermatitis. Iodochlorhydroxyquinoline: Cross-sensitivity with other halogenated hydroxyquinolines. May discolour fair hair.