Maladox

Maladox

Maladox is an antimalarial schizonticide, used in the treatment of malaria. Pyrimethamine/sulfadoxine is an antimalarial agent

Brand Description

Indications

The combination is indicated for the treatment of Plasmodium falciparum malaria in those patients in whom chloroquine resistance is suspected.

Pharmacological Class

Sulfadoxine: sulphonamide. Pyrimethamine: amino-pyrimidine derivative.

Pharmacological Class

Antimalarial schizonticide

Mechanism Of Action

Sulphadoxine and pyrimethamine combination is an antimalarial agent which acts by reciprocal potentiation of its two components, achieved by a sequential blockade of two...

Sulphadoxine and pyrimethamine combination is an antimalarial agent which acts by reciprocal potentiation of its two components, achieved by a sequential blockade of two enzymes involved in the biosynthesis of folinic acid within the parasites.

Side Effects

Rare gastrointestinal disorders, allergic skin reactions, blood abnormalities.

Contraindications

The drug is contraindicated in patients with severe renal insufficiency, marked liver parenchymal damage or blood dyscrasias, hypersensitivity to pyrimethamine or sulphonamides, patients with documented megaloblastic anemia due to folate deficiency, infants < 2 months of age, pregnancy at term and during the nursing period.>

Observations

Adequate fluid intake must be maintained in order to prevent crystalluria and stone formation. If anorexia or vomiting occurs during the therapy, these adverse effects may be minimized by taking the drug with meals. Instruct the patient to seek medical attention and discontinue prophylactic therapy if sore throat, fever, arthralgia, cough, shortness of breath, pallor, purpura, jaundice or glossitis develop.>

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Maladox Tablets

Maladox is the combination of 2 antimalarials i.e. sulfadoxine and ...

Molecule
Sulphadoxine, Pyrimethamine

Packaging Unit
50X3 Tablets

Dosage
Adults: The combination is recommended as single adult doses of 1500 mg of sulphadoxine drug plus 75 mg pyrimethamine (25 mg of the sulfa component per kg as a single dose). Children: 2 - 11 months - (5 - 10 Kg) Half tablet. 1 - 5 years - (10.1 - 20 Kg) One tablet. 6 - 8 years - (20.1 - 30 Kg) One and half tablet. 9 - 11 years - (30.1 - 40 Kg) Two tablets.

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Maladox

Maladox

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Maladox Tablets

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